The History of Cancer

The Historical Journey of Cancer Research

 

Cancer has been documented since the earliest medical records, with its history deeply intertwined with the evolution of medicine. The oldest known references to cancer come from seven ancient Egyptian papyri, discovered and translated in the late 19th century. Among these, the "Edwin Smith" and "George Ebers" papyri, dated around 1600 B.C. but possibly derived from sources as early as 2500 B.C., provide early insights into Egyptian medical practices. The Smith papyrus details surgical techniques, while the Ebers papyrus outlines treatments including pharmacological, mechanical, and magical approaches.

 

The ancient Egyptians demonstrated an advanced understanding of cancer, distinguishing between benign and malignant tumors and employing various treatments. As Egyptian civilization declined, medical knowledge transitioned to Greece and Rome, where prominent figures like Hippocrates and Galen revolutionized medical thought. They moved medicine away from magic and superstition, defining diseases as natural processes and emphasizing observation and experience. Hippocrates named cancer "karkinoma" (carcinoma), drawing a comparison between the appearance of tumors and the crab, due to the central body of the tumor and its extending "legs."

 

Following the fall of Rome, Constantinople became a central hub for preserving and transmitting medical knowledge. Greek and Roman texts were translated into Arabic and continued to influence medical practice in cities such as Cairo and Alexandria. During this period, cancer was still attributed to an excess of black bile and was thought to be curable only in its early stages.

 

The 16th and 17th centuries saw advancements in science and surgery, although the belief in black bile as the cause of cancer persisted. It wasn't until the 17th century, with Gaspare Aselli's discovery of the lymphatic system, that the theory began to shift towards abnormalities in lymph as a potential cause of cancer. French physician Claude Gendron challenged this theory in the 18th century, arguing that cancer originated locally as a hard mass and needed to be surgically removed.

 

In the 18th century, physicians like Jean Astruc and chemist Bernard Peyrilhe contributed to experimental oncology, establishing the foundation for modern cancer research despite some unconventional methods. This era also saw the establishment of hospitals specializing in cancer care and reports of environmental cancers.

 

The late 19th century marked a turning point with the development of advanced microscopes, which allowed scientists to examine cells and tumors in detail. This period revealed that cancer cells were distinctly different from normal cells, prompting research into cellular origins and disease behavior. The invention of the microscope was crucial in uncovering the nature of cancer cells.

 

The early 20th century brought significant progress in understanding cancer through cell culture, chemical carcinogens, and diagnostic techniques. Researchers explored various theories about cancer's origins, including viral, chemical, and chromosomal abnormalities. In 1911, a viral cause of cancer in chickens was documented, and both chemical and physical carcinogens were identified.

 

The 20th century also saw increased public awareness and education about cancer. In 1913, an article on cancer warning signs was published in a popular magazine, and a nationwide organization was formed to educate the public. By 1937, the U.S. Congress declared the fight against cancer a national goal with the establishment of the National Cancer Institute (NCI), which was tasked with advancing research and coordinating cancer-related projects. In 1971, President Richard M. Nixon signed the National Cancer Act, launching the National Cancer Program and further solidifying the U.S. commitment to combating cancer.