Induced Cancer Cells Death

Electric fields can trigger or programmed cell death in cancer cells. This controlled process removes damaged or unwanted cells without causing inflammation. Electric fields disrupt mitochondrial membrane potential and activate pro-apoptotic factors that start the cell death process. This targeted method selectively kills cancer cells while sparing healthy ones.

Disruption of Cancer Cells Cellular Structures 

Electric fields significantly affect the structure of cancer cells. By altering the arrangement of cellular parts like the cytoskeleton and plasma membrane, they impair the cells' ability to maintain their shape and function. This disruption hampers crucial processes like cell division and movement, ultimately reducing the tumor's ability to grow and spread.

Cancer Cells Membrane Ion Control 

Electric fields affect ion movement across the cell membrane, changing the cell's electrical properties. This ion transfer alters membrane potential and permeability, impacting cellular signaling and metabolism. By modifying these ion gradients, electric fields disrupt the balance within cancer cells, making them more vulnerable to treatment.

Enhanced Drug Delivery to Cancer Cells

Electric fields enhance the delivery and effectiveness of chemotherapy. By increasing the permeability of tumor blood vessels and cancer cell membranes, electric fields help more drugs enter the cancer cells. This improved delivery ensures higher concentrations of the drugs reach the target cells, making the treatment more effective and reducing overall side effects.

Boost Immune System 

Electric fields can boost the immune system's response to cancer. They trigger a type of cell death that makes tumor antigens more visible to the immune system, improving its ability to recognize and destroy cancer cells. This can lead to a stronger and longer-lasting anti-tumor response, aiding in long-term remission and reducing the risk of cancer spread.

Inhibition of New Blood Vessels on Cancer Cells

Angiogenesis, or the creation of new blood vessels, is crucial for tumor growth and spread. Electric fields can inhibit angiogenesis by disrupting the signaling pathways that control blood vessel formation. By limiting the supply of nutrients and oxygen to the tumor, electric fields help slow down tumor growth and reduce its ability to spread.

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Electroporation on Cancer Cells

Electric fields cause electroporation, where high-intensity electric pulses make cell membranes temporarily permeable. This allows therapeutic agents like DNA, RNA, or drugs to enter cancer cells more easily. Electroporation boosts the delivery of these agents inside the cells, making treatments more effective.

Cancer Cell Cycle Arrest

Electric fields can stop the cell cycle, especially during division of cancer cells. By disrupting cancer cell cycle progression, electric fields prevent cancer cells from dividing and growing. This interruption slows tumor growth and boosts the effectiveness of other treatments.

Cancer Cells DNA Damage and Repair Inhibition

Electric fields can directly damage the DNA of cancer cells and disrupt their repair mechanisms. This dual effect causes genetic damage to accumulate, leading to cell death and reducing the chances of cancer progression.